Typically, the damaging results of orlistat are short-term and moderate. Because the medicine is not systemically soaked up, the majority of unfavorable results are limited to the gastrointestinal tract and also are largely expansions of the pharmacologic activity of the drug. [Ref]

Throughout medical tests, roughly half of all events of GI negative occasions associated with orlistat treatment lasted much less compared to one week, and also a bulk lasted for no more compared to four weeks. Nonetheless, these negative side effects could take place in some individuals over a duration of 6 months or longer. A 42-year-old women knowledgeable irregularity, polyuria, polydipsia, and also increased lower-leg edema after 2 weeks of therapy with orlistat 120 milligrams 3 times daily. After the medicine was stopped for 4 days, the signs fixed. On reinstitution of the orlistat therapy, the symptoms re-emerged within 2 days. Afterwards, the medication was permanently ceased. [Ref]

Intestinal (GI) negative side effects consisting of oily spotting, flatus with discharge, fecal urgency, fatty or oily feces, oily evacuation, increased defecation, and fecal urinary incontinence have actually been reported in above or equivalent to 5 % of people. Cholelithiasis has been reported in 2.9 % of individuals versus 1.8 % in placebo. Various other GI negative effects potentially pertaining to orlistat treatment have included stomach pain and discomfort, nausea, infectious looseness of the bowels, rectal discomfort and soreness, tooth condition, gingival problem, and also throwing up. A minimum of one instance of irregular bowel movements has actually been reported. Pancreatitis has also been stated during postmarketing experience. [Ref]

  • Orlistat